The apartment building at 2 Fifth Avenue has been home to several notable LGBT figures who have made impacts in the fields of activism, health, theater, and literature.

One resident, Larry Kramer, (b. 1935) helped catalyze the response to the AIDS epidemic as co-founder of Gay Men’s Health Crisis (GMHC) and the AIDS Coalition to Unleash Power (ACT UP). His literary achievements as playwright include The Normal Heart (1985) and its sequel The Destiny of Me (1992). He is also well known for his controversial book Faggots (1978) and his screenplay of Women in Love (1969).

Edith “Edie” Windsor & Dr. Thea Clara Spyer also lived here. Edith “Edie” Windsor was a LGBT rights activist and her wife Thea Spyer moved into their apartment in the mid-1970s. Windsor, who resided here at the time of her death in 2017, was the lead plaintiff in the Supreme Court of the United States case, which overturned Section 3 of the Defense of Marriage Act.