Numerous health facilities were established in New York City following the outbreak of HIV and AIDS cases in the 1980s. From 1993 to 1994, this building was converted to Rivington House, a VillageCare-operated nursing home for people living with AIDS. The architecture firms of Perkins & Will and Davis, Brody & Associates were responsible for the conversion.

Rivington House opened in 1995 as the largest residential healthcare facility for AIDS patients in New York City and, perhaps, the nation. Equipped with 219 beds and an outpatient treatment center, it was originally considered an end-of-life nursing home for most of its patients; length of stay was 12 to 15 days and the death rate stood at nearly 50%. By 1997, new drug therapies were prolonging the lives of many people living with AIDS and, as a result, the death rate at Rivington House declined by 20% and the length of stay increased to 120 days.