Daily life in New York City continues to be upended from COVID-19. Businesses, bars, restaurants, schools and museums have been forced to close their doors. Although these feel like entirely unprecedented times, the city has experienced public health crises before. One hundred years ago, conditions were ripe for the spread of infections. And not unlike today, marginalized communities, like new immigrant populations, often bore the brunt of the bad conditions and consequences. Many immigrant neighborhoods offered substandard housing, packing large families in tiny, dingy apartments. Globalization was increasing and people and goods were traveling more and farther. So was disease. All these factors contribute to New York City’s long and dirty history of disease and illness, especially on the Lower East Side.