New York City’s oldest extant building originally built as a synagogue is this Gothic Revival structure designed by architect Alexander Saeltzer. The synagogue was built in 1849 by Reformed Jewish Congregation Ansche Chesed (People of Kindness) which was made up primarily of German Jews, as well as Dutch Jews and Polish Jews. (This group generally emigrated to New York City a few decades earlier than the wave of Eastern European Jews who later populated the Lower East Side so densely.)

It was the largest synagogue in the United States at the time and could hold up to 1,500 worshipers. Services were conducted primarily in German. Services were accompanied by musical instruments, including an organ that was added in 1869 at the same time as family pews were introduced, with men and women sitting together - evidence that the congregation was modernizing and Americanizing.

In 1873, the congregation merged with another and the building was sold to Orthodox Congregation Shaari Rachmim. Shari Rachmim removed the organ and remained in the building until 1886. Then, First Hungarian Congregation Ohab Zedek occupied the building until 1921 and Congregation Anshe Slonim worshipped there from 1921 to 1974.

Like so many others, the 1970s brought abandonment and decay to the historic building until it was rescued by artist Angel Orensanz in 1986. It was designated a historic landmark in 1987 and is now used as a well-known and beloved event space.