"Manhattan’s major waterfront area in the late nineteenth century was located in the Fourth Ward, a district that formed an apron around the Manhattan side of the Brooklyn Bridge. In 1885, the Fourth Ward contained 30 acres of tenements that housed around 17,000 people. The area had been awash with cheap groceries, rat pits, and stale beer dives for years, and due to the growing population of transient sailors, prostitute traffic thickened exponentially; at this time in New York history, the Fourth Ward was, as historian Timothy Gilfoyle describes it, 'the most significant and the poorest waterfront zone of prostitution.' But the waterfront was also the centerpiece of an international trade city, signifying plurality and opacity. Significantly, the district appealed to no one ethnicity, class, race, or gender. Ethnically cohesive neighborhoods, or 'ghettoes,' would only emerge when jobs and industries became associated with specific ethnic groups–garments for the Jewish, cigars for the Bohemians, etc. But through the 1870s and ’80s, the East Side waterfront region of New York, though perhaps mainly Irish, was still composed of workers and unemployed groups that largely allied themselves with trade and the lifestyle of the wharves rather than with any particular language, religion, or national origin."
For more on the Fourth Ward Waterfront, check out this article by Robert M. Dowling in Gotham: A Blog for Scholars of New York City History.