"On a rainy March morning in 1893, the life of a young nurse named Lillian Wald changed forever. Wald was giving a lesson in bed-making at a school on the Lower East Side when a young girl appeared and hurriedly requested that Wald attend to her sick mother. Following the girl over broken roadways, 'dirty mattresses,' and 'heaps of refuse'; passing 'reeking' tenement houses… Wald finally arrived at the crowded apartment where a woman had hemorrhaged during childbirth. Seeing the woman’s 'wretched' and 'pitiful' state and providing aid to a family with nowhere else to turn had a profound effect on Wald. 'Within a half an hour' of coming to this woman’s assistance, Wald later wrote, she had determined that she would move to the Lower East Side. Within six months Wald and her fellow nurse Mary Brewster had rented an apartment on Jefferson Street and begun a mission to provide health care to their new community. In 1895 Wald and her nurses’ settlement moved into a house on Henry Street purchased for her by philanthropist Jacob Schiff. The organization, taking its name from its new address, would become known as the Henry Street Settlement."
For more on Henry Street and other 'settlements' in New York City, check out this article by Ralph da Costa Nunez and Ethan G. Sribnick in Gotham: A Blog for Scholars of New York City History.